Formulation Of Sustained Release Ondansetron HCl Pediatric Suspension Using Ion Exchange Resin

Ondansetron Hydrochloride (ODH) is 5-HT3 receptor antagonists and is used for pediatric formulation. It is an antiemetic drug given in treatment of nausea and vomiting. The bitter taste of the drug and having shorter half-life and needed frequent administration which reduces patient compliance. Hence, need was felt to deliver ODH to the patients, once a day to improve the patient compliance of drug.So in the work undertaken, an attempt was made to sustain the release and to mask the taste of the ODH using ion exchange resin approach. Method used was complexation with ion exchange resin (Indion 244). The drug resin complex (DRC) was prepared by conventional batch method and microencapsulated with Eudragit RS 100 and ethylcellulose. The complex product was characterized by IR, DSC, drug content, in vitro dissolution and micrometric properties. The taste evaluation was done by an in-vitro and panel method. Drug release of complex showed that release was more than 70 % within 6 hr .where as Pure ODH enclosed in capsule more than 90 % within 2hr. respectively. The release of the drug is retarded from 62% to 48% for EC5%-20% and 58% to 45% for EU5%-20% and bitter sensation after 60 s. Thus it can be concluded that release of Ondansetron HCL is sustained and its taste can be masked using ion exchange resin complexation method.